| Reaction Details |
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 | Report a problem with these data |
| Target | RuvB-like 1 |
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| Ligand | BDBM15169 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2233429 (CHEMBL5147201) |
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| IC50 | 24000±n/a nM |
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| Citation |  Zhang, G; Wang, F; Li, S; Cheng, KW; Zhu, Y; Huo, R; Abdukirim, E; Kang, G; Chou, TF Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem62:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RuvB-like 1 |
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| Name: | RuvB-like 1 |
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| Synonyms: | 49 kDa TATA box-binding protein-interacting protein | 49 kDa TBP-interacting protein | 54 kDa erythrocyte cytosolic protein | ECP-54 | INO80 complex subunit H | INO80H | NMP 238 | NMP238 | Nuclear matrix protein 238 | Pontin 52 | RUVB1_HUMAN | RUVBL1 | TAP54-alpha | TIP49 | TIP49A | TIP60-associated protein 54-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50226.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108308 |
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| Residue: | 456 |
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| Sequence: | MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
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| BDBM15169 |
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| n/a |
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| Name | BDBM15169 |
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| Synonyms: | 1-{1-[(4-{7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl}phenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one | 3-[1-[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)benzyl]-4-piperidyl]-1H-benzimidazol-2-one | imidazoquinoxaline | imidazoquinoxaline 16h |
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| Type | Small organic molecule |
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| Emp. Form. | C34H29N7O |
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| Mol. Mass. | 551.6404 |
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| SMILES | O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4[nH]cnc4cc3nc2-c2ccccc2)CC1 |
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| Structure | 
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