| Reaction Details |
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 | Report a problem with these data |
| Target | RuvB-like 1 |
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| Ligand | BDBM85674 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2233429 (CHEMBL5147201) |
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| IC50 | 13000±n/a nM |
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| Citation |  Zhang, G; Wang, F; Li, S; Cheng, KW; Zhu, Y; Huo, R; Abdukirim, E; Kang, G; Chou, TF Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem62:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RuvB-like 1 |
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| Name: | RuvB-like 1 |
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| Synonyms: | 49 kDa TATA box-binding protein-interacting protein | 49 kDa TBP-interacting protein | 54 kDa erythrocyte cytosolic protein | ECP-54 | INO80 complex subunit H | INO80H | NMP 238 | NMP238 | Nuclear matrix protein 238 | Pontin 52 | RUVB1_HUMAN | RUVBL1 | TAP54-alpha | TIP49 | TIP49A | TIP60-associated protein 54-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50226.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108308 |
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| Residue: | 456 |
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| Sequence: | MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
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| BDBM85674 |
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| n/a |
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| Name | BDBM85674 |
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| Synonyms: | CAS_103177-37-3 | NSC_115100 | Pranlukast |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23N5O4 |
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| Mol. Mass. | 481.5026 |
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| SMILES | O=C(Nc1ccc2c(c1)oc(cc2=O)-c1nnn[nH]1)c1ccc(OCCCCc2ccccc2)cc1 |
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| Structure | 
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