| Reaction Details |
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 | Report a problem with these data |
| Target | Legumain |
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| Ligand | BDBM50600329 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2233774 (CHEMBL5147546) |
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| IC50 | 498±n/a nM |
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| Citation |  Calugi, L; Lenci, E; Bianchini, F; Contini, A; Trabocchi, A Modular synthesis of 2,4-diaminoanilines as CNS drug-like non-covalent inhibitors of asparagine endopeptidase. Bioorg Med Chem63:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Legumain |
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| Name: | Legumain |
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| Synonyms: | 3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1 |
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| Type: | n/a |
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| Mol. Mass.: | 49411.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 433 |
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| Sequence: | MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
IKLSMDHVCLGHY
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| BDBM50600329 |
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| n/a |
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| Name | BDBM50600329 |
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| Synonyms: | CHEMBL5197937 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H21N3OS |
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| Mol. Mass. | 279.401 |
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| SMILES | Nc1ccc(cc1N1CCSCC1)N1CCOCC1 |
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| Structure | 
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