| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Legumain |
|---|
| Ligand | BDBM50600333 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2233774 (CHEMBL5147546) |
|---|
| IC50 | 89±n/a nM |
|---|
| Citation |  Calugi, L; Lenci, E; Bianchini, F; Contini, A; Trabocchi, A Modular synthesis of 2,4-diaminoanilines as CNS drug-like non-covalent inhibitors of asparagine endopeptidase. Bioorg Med Chem63:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Legumain |
|---|
| Name: | Legumain |
|---|
| Synonyms: | 3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 49411.12 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 433 |
|---|
| Sequence: | MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
IKLSMDHVCLGHY
|
|
|
|---|
| BDBM50600333 |
|---|
| n/a |
|---|
| Name | BDBM50600333 |
|---|
| Synonyms: | CHEMBL5183094 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H27N3O3 |
|---|
| Mol. Mass. | 333.4253 |
|---|
| SMILES | CCOC(=O)C1CCN(CC1)c1cc(ccc1N)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
