| Reaction Details |
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 | Report a problem with these data |
| Target | Thrombopoietin receptor |
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| Ligand | BDBM50179471 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_338314 (CHEMBL866538) |
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| EC50 | 1000±n/a nM |
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| Citation |  Safonov, IG; Heerding, DA; Keenan, RM; Price, AT; Erickson-Miller, CL; Hopson, CB; Levin, JL; Lord, KA; Tapley, PM New benzimidazoles as thrombopoietin receptor agonists. Bioorg Med Chem Lett16:1212-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thrombopoietin receptor |
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| Name: | Thrombopoietin receptor |
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| Synonyms: | C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71243.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_535587 |
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| Residue: | 635 |
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| Sequence: | MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
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| BDBM50179471 |
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| n/a |
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| Name | BDBM50179471 |
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| Synonyms: | 5-[1-[2-(4'-tert-Butyl-2-hydroxy-biphenyl-3-yl)-1H-benzoimidazol-5-yl]-methylidene]-2-thioxo-thiazolidin-4-one | CHEMBL205027 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23N3O2S2 |
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| Mol. Mass. | 485.62 |
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| SMILES | CC(C)(C)c1ccc(cc1)-c1cccc(-c2nc3ccc(C=C4SC(=S)NC4=O)cc3[nH]2)c1O |w:21.21| |
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| Structure | 
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