| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease inhibitor A3N |
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| Ligand | BDBM50600940 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2235403 (CHEMBL5149175) |
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| EC50 | 11200±n/a nM |
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| Citation |  Colini Baldeschi, A; Zattoni, M; Vanni, S; Nikolic, L; Ferracin, C; La Sala, G; Summa, M; Bertorelli, R; Bertozzi, SM; Giachin, G; Carloni, P; Bolognesi, ML; De Vivo, M; Legname, G Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance. J Med Chem65:8998-9010 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease inhibitor A3N |
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| Name: | Serine protease inhibitor A3N |
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| Synonyms: | SPA3N_MOUSE | Serpin A3N | Serpina3n | Spi2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46713.95 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_120723 |
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| Residue: | 418 |
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| Sequence: | MAFIAALGLLMAGICPAVLCFPDGTLGMDAAVQEDHDNGTQLDSLTLASINTDFAFSLYK
ELVLKNPDKNIVFSPLSISAALAVMSLGAKGNTLEEILEGLKFNLTETSEADIHQGFGHL
LQRLNQPKDQVQISTGSALFIEKRQQILTEFQEKAKTLYQAEAFTADFQQPRQAKKLIND
YVRKQTQGMIKELVSDLDKRTLMVLVNYIYFKAKWKVPFDPLDTFKSEFYAGKRRPVIVP
MMSMEDLTTPYFRDEELSCTVVELKYTGNASALFILPDQGRMQQVEASLQPETLRKWKNS
LKPRMIDELHLPKFSISTDYSLEDVLSKLGIREVFSTQADLSAITGTKDLRVSQVVHKAV
LDVAETGTEAAAATGVKFVPMSAKLYPLTVYFNRPFLIMIFDTETEIAPFIAKIANPK
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| BDBM50600940 |
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| n/a |
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| Name | BDBM50600940 |
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| Synonyms: | CHEMBL5081846 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17F3N4O2 |
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| Mol. Mass. | 354.327 |
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| SMILES | Nc1c(cnn1-c1ccc(OC(F)(F)F)cc1)C(=O)C1CCNCC1 |
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| Structure | 
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