Reaction Details |
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Target | Telomerase reverse transcriptase |
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Ligand | BDBM50180773 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_327150 (CHEMBL864040) |
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EC50 | 146±n/a nM |
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Citation | Moore, MJ; Schultes, CM; Cuesta, J; Cuenca, F; Gunaratnam, M; Tanious, FA; Wilson, WD; Neidle, S Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. J Med Chem49:582-99 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Telomerase reverse transcriptase |
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Name: | Telomerase reverse transcriptase |
Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
Type: | PROTEIN |
Mol. Mass.: | 127099.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1447029 |
Residue: | 1132 |
Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
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BDBM50180773 |
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n/a |
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Name | BDBM50180773 |
Synonyms: | 3,6-bis[6-(pyrrolidin-1-yl)hexanamido]-9-{4'-[3''-(pyrrolidin-1-yl)propanamido]anilino}acridine | CHEMBL383282 |
Type | Small organic molecule |
Emp. Form. | C46H62N8O3 |
Mol. Mass. | 775.0363 |
SMILES | O=C(CCCCCN1CCCC1)Nc1ccc2c(Nc3ccc(NC(=O)CCN4CCCC4)cc3)c3ccc(NC(=O)CCCCCN4CCCC4)cc3nc2c1 |
Structure |
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