Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Beta-secretase 1 |
---|
Ligand | BDBM50601401 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2236325 (CHEMBL5150221) |
---|
IC50 | 1.1±n/a nM |
---|
Citation | Maia, M; Resende, DISP; Durães, F; Pinto, MMM; Sousa, E Xanthenes in Medicinal Chemistry - Synthetic strategies and biological activities. Eur J Med Chem210:0 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Beta-secretase 1 |
---|
Name: | Beta-secretase 1 |
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
Type: | Protein |
Mol. Mass.: | 55755.10 |
Organism: | Homo sapiens (Human) |
Description: | P56817 |
Residue: | 501 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
|
|
|
BDBM50601401 |
---|
n/a |
---|
Name | BDBM50601401 |
Synonyms: | CHEMBL5201184 |
Type | Small organic molecule |
Emp. Form. | C25H29FN4O2S |
Mol. Mass. | 468.587 |
SMILES | [H][C@]12CC[C@@H](C[C@]1([H])C1(CSC(N)=N1)c1cc(ccc1O2)-c1cncc(F)c1)NC(=O)C(C)(C)C |r,c:13| |
Structure |
|