Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase 26

Ligand

BDBM50601538

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2237505 (CHEMBL5151401)

IC50

34000±n/a nM

Citation

Tesch, R; Rak, M; Raab, M; Berger, LM; Kronenberger, T; Joerger, AC; Berger, BT; Abdi, I; Hanke, T; Poso, A; Strebhardt, K; Sanhaji, M; Knapp, S Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. J Med Chem64:8142-8160 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase 26

Name:

Serine/threonine-protein kinase 26

Synonyms:

MASK | MST4 | STK26 | STK26_HUMAN | Serine/threonine-protein kinase MST4

Type:

PROTEIN

Mol. Mass.:

46517.68

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1510631

Residue:

416

Sequence:

MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA
EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ
IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV
GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV
GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS
DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA
FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP

BDBM50601538

n/a

Name

BDBM50601538

Synonyms:

CHEMBL5090394

Type

Small organic molecule

Emp. Form.

C24H22ClFN6O3

Mol. Mass.

496.921

SMILES

CNc1ncc2cc(-c3ccc(cc3Cl)-c3ncccc3F)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 |r,wU:29.31,wD:26.27,(3.85,-1.33,;3.08,,;1.54,,;.77,-1.33,;-.77,-1.33,;-1.54,,;-3.08,,;-3.85,1.33,;-5.39,1.33,;-6.16,2.67,;-7.7,2.67,;-8.47,1.33,;-7.7,,;-6.16,,;-5.39,-1.33,;-10.01,1.33,;-10.78,2.67,;-12.32,2.67,;-13.09,1.33,;-12.32,,;-10.78,,;-10.01,-1.33,;-3.08,2.67,;-3.85,4,;-1.54,2.67,;-.77,4,;.77,4,;1.54,2.67,;3.08,2.67,;3.85,4,;5.39,4,;3.08,5.33,;1.54,5.33,;-.77,1.33,;.77,1.33,)|

Structure