| Reaction Details |
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 | Report a problem with these data |
| Target | Furin |
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| Ligand | BDBM50601715 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2237971 (CHEMBL5151867) |
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| Ki | 1.2±n/a nM |
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| Citation |  Osman, EEA; Rehemtulla, A; Neamati, N Why All the Fury over Furin? J Med Chem65:2747-2784 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Furin |
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| Name: | Furin |
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| Synonyms: | FUR | FURIN | FURIN_HUMAN | Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA | PACE | PCSK3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 86676.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09958 |
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| Residue: | 794 |
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| Sequence: | MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
RGERTAFIKDQSAL
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| BDBM50601715 |
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| n/a |
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| Name | BDBM50601715 |
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| Synonyms: | CHEMBL5189192 |
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| Type | Small organic molecule |
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| Emp. Form. | C52H83N17O8 |
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| Mol. Mass. | 1074.3245 |
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| SMILES | CC(C)(C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCCNC(=O)Cc2ccc(CNC(=O)CCCC(=O)NCCCC[C@H](NC1=O)C(=O)NCc1ccc(cc1)C(N)=N)cc2 |r| |
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| Structure | 
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