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TargetPotassium voltage-gated channel subfamily A member 4
LigandBDBM50182587
Substrate/Competitorn/a
Meas. Tech.ChEMBL_334899 (CHEMBL861277)
EC50 4800±n/a nM
Citation Harvey, AJBaell, JBToovey, NHomerick, DWulff, H A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone. J Med Chem49:1433-41 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium voltage-gated channel subfamily A member 4
Name:Potassium voltage-gated channel subfamily A member 4
Synonyms:KCNA4 | KCNA4L | KCNA4_HUMAN | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.4
Type:PROTEIN
Mol. Mass.:73234.81
Organism:Homo sapiens (Human)
Description:ChEMBL_471773
Residue:653
Sequence:
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGG
SHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE
LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI
NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR
LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP
ESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE
NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG
TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL
LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV
GSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS
TSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50182587
n/a
NameBDBM50182587
Synonyms:5-acetyl-4-(4'-chloro)benzyloxy-6-hydroxy-7-methoxybenzofuran | CHEMBL382154
TypeSmall organic molecule
Emp. Form.C18H15ClO5
Mol. Mass.346.762
SMILESCOc1c(O)c(C(C)=O)c(OCc2ccc(Cl)cc2)c2ccoc12
Structure
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