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TargetGlycogen synthase kinase-3 beta
LigandBDBM50602863
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2242298 (CHEMBL5156508)
IC50 9.5±n/a nM
Citation Demuro, S; Sauvey, C; Tripathi, SK; Di Martino, RMC; Shi, D; Ortega, JA; Russo, D; Balboni, B; Giabbai, B; Storici, P; Girotto, S; Abagyan, R; Cavalli, A ARN25068, a versatile starting point towards triple GSK-3?/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem229:0 (2022) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50602863
n/a
NameBDBM50602863
Synonyms:CHEMBL1997924
TypeSmall organic molecule
Emp. Form.C19H18N6S
Mol. Mass.362.451
SMILESC(Nc1nc(Nc2cc([nH]n2)C2CC2)c2sccc2n1)c1ccccc1
Structure
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