| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50184677 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_355753 (CHEMBL861104) |
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| IC50 | 15±n/a nM |
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| Citation |  Guare, JP; Wai, JS; Gomez, RP; Anthony, NJ; Jolly, SM; Cortes, AR; Vacca, JP; Felock, PJ; Stillmock, KA; Schleif, WA; Moyer, G; Gabryelski, LJ; Jin, L; Chen, IW; Hazuda, DJ; Young, SD A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors. Bioorg Med Chem Lett16:2900-4 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50184677 |
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| n/a |
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| Name | BDBM50184677 |
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| Synonyms: | CHEMBL378029 | N-(4-fluorobenzyl)-8-hydroxy-5-(N-methyl-2-(methylamino)-2-oxoacetamido)-1,6-naphthyridine-7-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18FN5O4 |
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| Mol. Mass. | 411.3864 |
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| SMILES | CNC(=O)C(=O)N(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c2ncccc12 |
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| Structure | 
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