| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 2 |
|---|
| Ligand | BDBM110036 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2244140 (CHEMBL5158350) |
|---|
| IC50 | >5000±n/a nM |
|---|
| Citation |  Nawar, N; Bukhari, S; Adile, AA; Suk, Y; Manaswiyoungkul, P; Toutah, K; Olaoye, OO; Raouf, YS; Sedighi, A; Garcha, HK; Hassan, MM; Gwynne, W; Israelian, J; Radu, TB; Geletu, M; Abdeldayem, A; Gawel, JM; Cabral, AD; Venugopal, C; de Araujo, ED; Singh, SK; Gunning, PT Discovery of HDAC6-Selective Inhibitor NN-390 with J Med Chem65:3193-3217 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 2 |
|---|
| Name: | Histone deacetylase 2 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 55356.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q92769 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
|
|
|
|---|
| BDBM110036 |
|---|
| n/a |
|---|
| Name | BDBM110036 |
|---|
| Synonyms: | US8609678, 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [89] |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H26ClN5O3 |
|---|
| Mol. Mass. | 467.948 |
|---|
| SMILES | ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1)c1ccccc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
