| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Steryl-sulfatase |
|---|
| Ligand | BDBM50604012 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2246270 (CHEMBL5160480) |
|---|
| IC50 | 0.210000±n/a nM |
|---|
| Citation |  Biernacki, K; Ciupak, O; Da?ko, M; Rachon, J; Kozak, W; Rak, J; Kubi?ski, K; Mas?yk, M; Martyna, A; ?liwka-Kaszy?ska, M; Wietrzyk, J; ?witalska, M; Nocentini, A; Supuran, CT; Demkowicz, S Development of Sulfamoylated 4-(1-Phenyl-1 J Med Chem65:5044-5056 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Steryl-sulfatase |
|---|
| Name: | Steryl-sulfatase |
|---|
| Synonyms: | ARSC1 | ASC | Arylsulfatase C | STS | STS_HUMAN | Steroid sulfatase | Steryl-sulfate sulfohydrolase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 65503.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08842 |
|---|
| Residue: | 583 |
|---|
| Sequence: | MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
|
|
|
|---|
| BDBM50604012 |
|---|
| n/a |
|---|
| Name | BDBM50604012 |
|---|
| Synonyms: | CHEMBL5199004 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H10F2N4O3S |
|---|
| Mol. Mass. | 352.316 |
|---|
| SMILES | NS(=O)(=O)Oc1ccc(cc1)-c1cn(nn1)-c1cc(F)cc(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
