Reaction Details |
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Target | fMet-Leu-Phe receptor |
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Ligand | BDBM50604079 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2246779 (CHEMBL5160989) |
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EC50 | 6800±n/a nM |
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Citation | Mastromarino, M; Favia, M; Schepetkin, IA; Kirpotina, LN; Trojan, E; Niso, M; Carrieri, A; Le?kiewicz, M; Regulska, M; Darida, M; Rossignolo, F; Fontana, S; Quinn, MT; Basta-Kaim, A; Leopoldo, M; Lacivita, E Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders. J Med Chem65:5004-5028 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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fMet-Leu-Phe receptor |
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Name: | fMet-Leu-Phe receptor |
Synonyms: | FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 38456.14 |
Organism: | Homo sapiens (Human) |
Description: | gi_4503779 |
Residue: | 350 |
Sequence: | METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVT
TISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIA
LDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNF
SPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPL
RVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPML
YVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
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BDBM50604079 |
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n/a |
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Name | BDBM50604079 |
Synonyms: | CHEMBL5187530 |
Type | Small organic molecule |
Emp. Form. | C22H23FN4O2 |
Mol. Mass. | 394.442 |
SMILES | Fc1ccc(NC(=O)N[C@@H](Cc2ccc(cc2)C#N)C(=O)N2CCCCC2)cc1 |r| |
Structure |
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