| Reaction Details |
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 | Report a problem with these data |
| Target | Adenylate cyclase type 1 |
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| Ligand | BDBM50604203 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2247166 (CHEMBL5161376) |
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| IC50 | 2200±n/a nM |
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| Citation |  Scott, JA; Soto-Velasquez, M; Hayes, MP; LaVigne, JE; Miller, HR; Kaur, J; Ejendal, KFK; Watts, VJ; Flaherty, DP Optimization of a Pyrimidinone Series for Selective Inhibition of Ca J Med Chem65:4667-4686 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenylate cyclase type 1 |
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| Name: | Adenylate cyclase type 1 |
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| Synonyms: | ADCY1 | ADCY1_HUMAN | Adenylate cyclase | Brain adenylate cyclase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 123469.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_31877 |
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| Residue: | 1119 |
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| Sequence: | MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAA
TLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQ
QVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVR
SLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQR
KAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHD
NVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL
TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS
NDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSH
RRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALR
TASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQK
YHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRV
QCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALP
TLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAV
SGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNL
LPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEI
IADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFD
VLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQV
TEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRA
GLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA
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| BDBM50604203 |
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| n/a |
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| Name | BDBM50604203 |
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| Synonyms: | CHEMBL5203795 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N5O2 |
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| Mol. Mass. | 337.3758 |
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| SMILES | CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccccc1C |
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| Structure | 
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