| Reaction Details |
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 | Report a problem with these data |
| Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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| Ligand | BDBM50187686 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2251314 (CHEMBL5165524) |
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| IC50 | 131±n/a nM |
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| Citation |  Clark, JM; Salgado-Polo, F; Macdonald, SJF; Barrett, TN; Perrakis, A; Jamieson, C Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators. J Med Chem65:6338-6351 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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| Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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| Synonyms: | 3.1.4.39 | Atx | Autotaxin | E-NPP 2 | ENPP2_RAT | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enpp2 | Extracellular lysophospholipase D | LysoPLD | Npps2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 101590.86 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_116829 |
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| Residue: | 887 |
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| Sequence: | MARQGCLGSFQVISLFTFAISVNICLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKG
RCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCS
EDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKK
GSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDAS
FHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERP
SVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHG
MEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSKYDPKTIIANLTCKKPDQHF
KPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFFQGDHGFDNKV
NSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFR
PTMPDEVSRPNYPGIMYLQSEFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEAETGKFRG
SKHENKKNLNGSVEPRKERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTI
SKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDA
FLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQY
VEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWV
EELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI
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| BDBM50187686 |
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| n/a |
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| Name | BDBM50187686 |
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| Synonyms: | CHEMBL3828074 | US10526329, Compound 2 | US11072611, Compound 2 | US11104665, WO2014/139882 Example 2 | US11591342, Compound GLPG1690 | US20230295159, Example GLPG1690 | US9670204, 2 2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile | WO2014139882, Compound 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33FN8O2S |
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| Mol. Mass. | 588.699 |
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| SMILES | CCc1nc2c(C)cc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)N1CCN(CC(=O)N2CC(O)C2)CC1 |
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| Structure | 
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