| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Monoglyceride lipase |
|---|
| Ligand | BDBM50605685 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2252660 (CHEMBL5166870) |
|---|
| IC50 | 125±n/a nM |
|---|
| Citation |  Bononi, G; Di Stefano, M; Poli, G; Ortore, G; Meier, P; Masetto, F; Caligiuri, I; Rizzolio, F; Macchia, M; Chicca, A; Avan, A; Giovannetti, E; Vagaggini, C; Brai, A; Dreassi, E; Valoti, M; Minutolo, F; Granchi, C; Gertsch, J; Tuccinardi, T Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives. J Med Chem65:7118-7140 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Monoglyceride lipase |
|---|
| Name: | Monoglyceride lipase |
|---|
| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
|---|
| Type: | Hydrolase |
|---|
| Mol. Mass.: | 33264.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
|---|
| Residue: | 303 |
|---|
| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
|
|
|
|---|
| BDBM50605685 |
|---|
| n/a |
|---|
| Name | BDBM50605685 |
|---|
| Synonyms: | CHEMBL5188296 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H22ClF3N2O3 |
|---|
| Mol. Mass. | 490.902 |
|---|
| SMILES | Oc1ccc(Cl)c(c1)C(=O)N1CCC(Cc2cccc(Oc3ccc(cn3)C(F)(F)F)c2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
