Reaction Details |
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Target | Monoglyceride lipase |
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Ligand | BDBM50605682 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2252660 (CHEMBL5166870) |
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IC50 | 2.0±n/a nM |
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Citation | Bononi, G; Di Stefano, M; Poli, G; Ortore, G; Meier, P; Masetto, F; Caligiuri, I; Rizzolio, F; Macchia, M; Chicca, A; Avan, A; Giovannetti, E; Vagaggini, C; Brai, A; Dreassi, E; Valoti, M; Minutolo, F; Granchi, C; Gertsch, J; Tuccinardi, T Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives. J Med Chem65:7118-7140 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Monoglyceride lipase |
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Name: | Monoglyceride lipase |
Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
Type: | Hydrolase |
Mol. Mass.: | 33264.56 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
Residue: | 303 |
Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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BDBM50605682 |
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n/a |
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Name | BDBM50605682 |
Synonyms: | CHEMBL5176915 |
Type | Small organic molecule |
Emp. Form. | C25H22F4N2O3 |
Mol. Mass. | 474.4474 |
SMILES | Oc1ccc(F)c(c1)C(=O)N1CCC(Cc2cccc(Oc3cc(ccn3)C(F)(F)F)c2)CC1 |
Structure |
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