| Reaction Details |
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 | Report a problem with these data |
| Target | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Ligand | BDBM601015 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2252691 (CHEMBL5166901) |
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| IC50 | 9.5±n/a nM |
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| Citation |  Willis, NJ; Mahy, W; Sipthorp, J; Zhao, Y; Woodward, HL; Atkinson, BN; Bayle, ED; Svensson, F; Frew, S; Jeganathan, F; Monaghan, A; Benvegnù, S; Jolly, S; Vecchia, L; Ruza, RR; Kjær, S; Howell, S; Snijders, AP; Bictash, M; Salinas, PC; Vincent, JP; Jones, EY; Whiting, P; Fish, PV Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J Med Chem65:7212-7230 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Palmitoleoyl-protein carboxylesterase NOTUM |
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| Name: | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Synonyms: | NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55706.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116492 |
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| Residue: | 496 |
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| Sequence: | MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVE
GNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRW
LLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFI
PYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLL
NVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNG
VVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGL
RLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHD
SHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQP
QGLEPSELLGMLSNGS
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| BDBM601015 |
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| n/a |
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| Name | BDBM601015 |
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| Synonyms: | US11634391, Compound 277 | [1-[2,4-dichloro-3-(trifluoromethyl)phenyl]triazol-4-yl]methanol |
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| Type | Small organic molecule |
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| Emp. Form. | C10H6Cl2F3N3O |
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| Mol. Mass. | 312.075 |
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| SMILES | OCc1cn(nn1)-c1ccc(Cl)c(c1Cl)C(F)(F)F |
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| Structure | 
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