Reaction Details |
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Target | B-cell lymphoma 6 protein |
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Ligand | BDBM50606283 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2254352 (CHEMBL5168562) |
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IC50 | 4.6±n/a nM |
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Citation | Huckvale, R; Harnden, AC; Cheung, KJ; Pierrat, OA; Talbot, R; Box, GM; Henley, AT; de Haven Brandon, AK; Hallsworth, AE; Bright, MD; Akpinar, HA; Miller, DSJ; Tarantino, D; Gowan, S; Hayes, A; Gunnell, EA; Brennan, A; Davis, OA; Johnson, LD; de Klerk, S; McAndrew, C; Le Bihan, YV; Meniconi, M; Burke, R; Kirkin, V; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Bellenie, BR; Hoelder, S Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 J Med Chem65:8191-8207 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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B-cell lymphoma 6 protein |
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Name: | B-cell lymphoma 6 protein |
Synonyms: | B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51 |
Type: | PROTEIN |
Mol. Mass.: | 78866.89 |
Organism: | Homo sapiens |
Description: | ChEMBL_117695 |
Residue: | 706 |
Sequence: | MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSI
FTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDT
CRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAF
APSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPG
EYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKAS
KEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASG
SPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEP
ENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGS
QSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQT
HSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEK
PYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHC
EKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
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BDBM50606283 |
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n/a |
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Name | BDBM50606283 |
Synonyms: | CHEMBL5174171 |
Type | Small organic molecule |
Emp. Form. | C25H25ClF4N6O3 |
Mol. Mass. | 568.951 |
SMILES | Cn1c2ccc(Nc3nc(ncc3Cl)N3CCC(F)(F)[C@H](O)C3)cc2c2N[C@@H](C3CC3)C(F)(F)COc2c1=O |r| |
Structure |
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