| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropilin-1 |
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| Ligand | BDBM50189004 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_389196 (CHEMBL867991) |
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| IC50 | 2000±n/a nM |
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| Citation |  Bedjeguelal, K; Bienaymé, H; Dumoulin, A; Poigny, S; Schmitt, P; Tam, E Discovery of protein-protein binding disruptors using multi-component condensations small molecules. Bioorg Med Chem Lett16:3998-4001 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropilin-1 |
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| Name: | Neuropilin-1 |
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| Synonyms: | Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 | NRP | NRP1 | NRP1_HUMAN | Neuropilin-1 | VEGF165R |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103122.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_617636 |
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| Residue: | 923 |
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| Sequence: | MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVP
KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV
DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTF
CHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAH
CMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVI
FEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGD
KNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYN
FELVDGVKLKKDKLNTQSTYSEA
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| BDBM50189004 |
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| n/a |
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| Name | BDBM50189004 |
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| Synonyms: | 5-chloro-2-phenethyl-3-(phenethylamino)indolizine-1-carbonitrile | CHEMBL215821 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22ClN3 |
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| Mol. Mass. | 399.915 |
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| SMILES | Clc1cccc2c(C#N)c(CCc3ccccc3)c(NCCc3ccccc3)n12 |
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| Structure | 
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