| Reaction Details |
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 | Report a problem with these data |
| Target | Pituitary adenylate cyclase-activating polypeptide type I receptor |
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| Ligand | BDBM50606528 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2260454 (CHEMBL5215465) |
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| IC50 | 3.5±n/a nM |
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| Citation |  Hu, E; Hong, FT; Aral, J; Long, J; Piper, DE; Poppe, L; Andrews, KL; Hager, T; Davis, C; Li, H; Wong, P; Gavva, N; Shi, L; Zhu, DXD; Lehto, SG; Xu, C; Miranda, LP Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model. J Med Chem64:3427-3438 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pituitary adenylate cyclase-activating polypeptide type I receptor |
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| Name: | Pituitary adenylate cyclase-activating polypeptide type I receptor |
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| Synonyms: | ADCYAP1R1 | PACR_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53307.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_498617 |
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| Residue: | 468 |
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| Sequence: | MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIP
LFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKV
NRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT
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| BDBM50606528 |
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| n/a |
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| Name | BDBM50606528 |
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| Synonyms: | CHEMBL5219662 |
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| Type | Small organic molecule |
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| Emp. Form. | C187H309N57O47S |
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| Mol. Mass. | 4139.873 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](CCS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O |r| |
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| Structure | 
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