| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-dependent RNA helicase DDX3X |
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| Ligand | BDBM50606859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2261439 (CHEMBL5216450) |
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| Ki | 100±n/a nM |
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| Citation |  Brai, A; Trivisani, CI; Poggialini, F; Pasqualini, C; Vagaggini, C; Dreassi, E DEAD-Box Helicase DDX3X as a Host Target against Emerging Viruses: New Insights for Medicinal Chemical Approaches. J Med Chem65:10195-10216 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-dependent RNA helicase DDX3X |
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| Name: | ATP-dependent RNA helicase DDX3X |
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| Synonyms: | DBX | DDX3 | DDX3X | DDX3X_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73247.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_811954 |
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| Residue: | 662 |
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| Sequence: | MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGW
SSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFE
RGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILS
QIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVV
YGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVV
WVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDR
EEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGAR
DYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWW
GN
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| BDBM50606859 |
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| n/a |
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| Name | BDBM50606859 |
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| Synonyms: | CHEMBL5219128 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21ClN2O5S2 |
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| Mol. Mass. | 492.996 |
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| SMILES | COc1cc(\C=C2/SC(=S)N(CCC(=O)Nc3ccccc3Cl)C2=O)cc(OC)c1OC |
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| Structure | 
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