| Reaction Details |
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 | Report a problem with these data |
| Target | NADPH oxidase 3 |
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| Ligand | BDBM318936 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2261582 (CHEMBL5216593) |
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| IC50 | 1250±n/a nM |
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| Citation |  Shahari, MSB; Dolzhenko, AV A closer look at N Eur J Med Chem241:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NADPH oxidase 3 |
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| Name: | NADPH oxidase 3 |
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| Synonyms: | 1.6.3.- | GP91-3 | MOX-2 | MOX2 | Mitogenic oxidase 2 | NOX3 | NOX3_HUMAN | gp91phox homolog 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64948.77 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_104012 |
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| Residue: | 568 |
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| Sequence: | MMGCWILNEGLSTILVLSWLGINFYLFIDTFYWYEEEESFHYTRVILGSTLAWARASALC
LNFNCMLILIPVSRNLISFIRGTSICCRGPWRRQLDKNLRFHKLVAYGIAVNATIHIVAH
FFNLERYHWSQSEEAQGLLAALSKLGNTPNESYLNPVRTFPTNTTTELLRTIAGVTGLVI
SLALVLIMTSSTEFIRQASYELFWYTHHVFIVFFLSLAIHGTGRIVRGQTQDSLSLHNIT
FCRDRYAEWQTVAQCPVPQFSGKEPSAWKWILGPVVLYACERIIRFWRFQQEVVITKVVS
HPSGVLELHMKKRGFKMAPGQYILVQCPAISSLEWHPFTLTSAPQEDFFSVHIRAAGDWT
AALLEAFGAEGQALQEPWSLPRLAVDGPFGTALTDVFHYPVCVCVAAGIGVTPFAALLKS
IWYKCSEAQTPLKLSKVYFYWICRDARAFEWFADLLLSLETRMSEQGKTHFLSYHIFLTG
WDENQALHIALHWDENTDVITGLKQKTFYGRPNWNNEFKQIAYNHPSSSIGVFFCGPKAL
SRTLQKMCHLYSSADPRGVHFYYNKESF
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| BDBM318936 |
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| n/a |
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| Name | BDBM318936 |
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| Synonyms: | US10173988, Compound A |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29N7O |
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| Mol. Mass. | 419.5227 |
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| SMILES | COc1cccc(c1)N1CCN(Cc2nc(N)nc(Nc3ccc(C)c(C)c3)n2)CC1 |
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| Structure | 
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