| Reaction Details |
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 | Report a problem with these data |
| Target | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Ligand | BDBM50607642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2263018 (CHEMBL5218029) |
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| IC50 | 2.3±n/a nM |
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| Citation |  Hu, B; Toda, K; Wang, X; Antczak, MI; Smith, J; Geboers, S; Nishikawa, G; Li, H; Dawson, D; Fink, S; Desai, AB; Williams, NS; Markowitz, SD; Ready, JM Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration. J Med Chem65:15327-15343 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Name: | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Synonyms: | 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 28974.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15428 |
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| Residue: | 266 |
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| Sequence: | MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
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| BDBM50607642 |
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| n/a |
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| Name | BDBM50607642 |
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| Synonyms: | CHEMBL5219503 | US11718589, Compound 48b |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20N4O |
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| Mol. Mass. | 368.4311 |
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| SMILES | O=C(N1CCCCC1)c1ccc2ncc(nc2c1)-c1ccc2ncccc2c1 |
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| Structure | 
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