Reaction Details |
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Target | Kinesin-like protein KIF18A |
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Ligand | BDBM50403999 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2264336 |
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IC50 | 165±n/a nM |
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Citation | Tamayo, NA; Bourbeau, MP; Allen, JR; Ashton, KS; Chen, JJ; Kaller, MR; Nguyen, TT; Nishimura, N; Pettus, LH; Walton, M; Belmontes, B; Moriguchi, J; Chen, K; McCarter, JD; Hanestad, K; Chung, G; Ninniri, MSS; Sun, J; Poppe, L; Spahr, C; Hui, J; Jia, L; Wu, T; Dahal, UP; Edson, KZ; Payton, M Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem65:4972-4990 (2022) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Kinesin-like protein KIF18A |
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Name: | Kinesin-like protein KIF18A |
Synonyms: | KI18A_HUMAN | KIF18A | Kinesin-like protein KIF18A | MS-KIF18A | Marrow stromal KIF18A |
Type: | PROTEIN |
Mol. Mass.: | 102320.22 |
Organism: | Homo sapiens |
Description: | ChEMBL_119153 |
Residue: | 898 |
Sequence: | MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTT
NQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKT
HTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVR
EDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQD
KTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKR
KNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLK
SNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIE
RFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKR
DHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHH
LHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESD
FKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVK
IPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTV
TLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSK
CKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNS
SLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR
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BDBM50403999 |
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n/a |
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Name | BDBM50403999 |
Synonyms: | CHEMBL5276902 |
Type | Small organic molecule |
Emp. Form. | C28H38N4O4S |
Mol. Mass. | 526.691 |
SMILES | CC(C)(O)CNc1ccc(C(=O)Nc2cccc(n2)S(=O)(=O)C2CCCC2)c(c1)N1CCC2(CC2)CC1 |
Structure |
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