| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF18A |
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| Ligand | BDBM50404034 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2264336 |
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| IC50 | 81±n/a nM |
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| Citation |  Tamayo, NA; Bourbeau, MP; Allen, JR; Ashton, KS; Chen, JJ; Kaller, MR; Nguyen, TT; Nishimura, N; Pettus, LH; Walton, M; Belmontes, B; Moriguchi, J; Chen, K; McCarter, JD; Hanestad, K; Chung, G; Ninniri, MSS; Sun, J; Poppe, L; Spahr, C; Hui, J; Jia, L; Wu, T; Dahal, UP; Edson, KZ; Payton, M Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem65:4972-4990 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIF18A |
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| Name: | Kinesin-like protein KIF18A |
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| Synonyms: | KI18A_HUMAN | KIF18A | Kinesin-like protein KIF18A | MS-KIF18A | Marrow stromal KIF18A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 102320.22 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119153 |
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| Residue: | 898 |
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| Sequence: | MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTT
NQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKT
HTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVR
EDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQD
KTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKR
KNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLK
SNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIE
RFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKR
DHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHH
LHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESD
FKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVK
IPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTV
TLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSK
CKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNS
SLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR
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| BDBM50404034 |
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| n/a |
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| Name | BDBM50404034 |
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| Synonyms: | CHEMBL5077043 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H38N6O4S |
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| Mol. Mass. | 530.683 |
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| SMILES | CC(C)(C)NS(=O)(=O)c1cccc(NC(=O)c2ccc(NC(C)(C)CO)nc2N2CCC3(CC3)CC2)n1 |
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| Structure | 
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