| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-K |
|---|
| Ligand | BDBM8131 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2264680 |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Huang, Z; Wang, T; Wang, C; Fan, Y CDK9 inhibitors in cancer research. RSC Med Chem13:688-710 (2022) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-K |
|---|
| Name: | Cyclin-K |
|---|
| Synonyms: | CCNK | CCNK_HUMAN | CPR4 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 64254.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107901 |
|---|
| Residue: | 580 |
|---|
| Sequence: | MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDV
GTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTA
RSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQK
LVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQ
DVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPS
QPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIET
THPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRP
PPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPP
NPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGL
PPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR
|
|
|
|---|
| BDBM8131 |
|---|
| n/a |
|---|
| Name | BDBM8131 |
|---|
| Synonyms: | N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine | N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine | pyrazolo[1,5-b]pyridazine deriv. 22 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18N6 |
|---|
| Mol. Mass. | 330.3864 |
|---|
| SMILES | CC(C)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
