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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase 9 | ||
| Ligand | BDBM354126 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2264730 | ||
| IC50 | 2.6±n/a nM | ||
| Citation |  Huang, Z; Wang, T; Wang, C; Fan, Y CDK9 inhibitors in cancer research. RSC Med Chem13:688-710 (2022) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase 9 | |||
| Name: | Cyclin-dependent kinase 9 | ||
| Synonyms: | C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 42789.13 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 372 | ||
| Sequence: |
| ||
| BDBM354126 | |||
| n/a | |||
| Name | BDBM354126 | ||
| Synonyms: | US9796708, Example 1358 | trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclohexanecarboxylic acid | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27F2N3O3 | ||
| Mol. Mass. | 467.5077 | ||
| SMILES | COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:28.35,wD:25.28,t:22,(6.53,-1.01,;5.2,-.24,;3.86,-1.01,;3.86,-2.55,;2.53,-3.32,;1.2,-2.55,;-.14,-3.32,;1.2,-1.01,;2.53,-.24,;2.53,1.3,;3.86,2.07,;5.2,1.3,;3.86,3.61,;2.53,4.38,;1.2,3.61,;-.27,4.09,;-1.17,2.84,;-.27,1.6,;1.2,2.07,;-2.71,2.84,;-3.48,4.18,;-5.02,4.18,;-5.79,2.84,;-5.02,1.51,;-3.48,1.51,;-7.33,2.84,;-8.1,4.18,;-9.64,4.18,;-10.41,2.84,;-9.64,1.51,;-8.1,1.51,;-11.95,2.84,;-12.72,1.51,;-12.72,4.18,)| | ||
| Structure | 
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