| Reaction Details |
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 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor |
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| Ligand | BDBM50192540 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_402775 (CHEMBL908626) |
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| Ki | 19±n/a nM |
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| Citation |  Burgey, CS; Stump, CA; Nguyen, DN; Deng, JZ; Quigley, AG; Norton, BR; Bell, IM; Mosser, SD; Salvatore, CA; Rutledge, RZ; Kane, SA; Koblan, KS; Vacca, JP; Graham, SL; Williams, TM Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine. Bioorg Med Chem Lett16:5052-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcitonin gene-related peptide type 1 receptor |
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| Name: | Calcitonin gene-related peptide type 1 receptor |
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| Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52980.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16602 |
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| Residue: | 461 |
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| Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
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| BDBM50192540 |
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| n/a |
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| Name | BDBM50192540 |
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| Synonyms: | (R)-4-(4-(4-(difluoromethoxy)phenyl)-2-oxo-2,3-dihydroimidazol-1-yl)-N-(2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)piperidine-1-carboxamide | CHEMBL386757 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H29F5N6O4 |
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| Mol. Mass. | 668.6132 |
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| SMILES | FC(F)Oc1ccc(cc1)-c1cn(C2CCN(CC2)C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)c(=O)[nH]1 |t:25| |
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| Structure | 
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