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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM50192684 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_422276 (CHEMBL855996) | ||
| IC50 | 22±n/a nM | ||
| Citation |  Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements. Bioorg Med Chem Lett16:5408-13 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM50192684 | |||
| n/a | |||
| Name | BDBM50192684 | ||
| Synonyms: | (3s,9s)-9-(2-(5-cyanopyridin-2-yloxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxamide | CHEMBL219295 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H26N4O3 | ||
| Mol. Mass. | 370.4454 | ||
| SMILES | CC(C)(Oc1ccc(cn1)C#N)C(=O)N[C@@H]1C2CCCC1C[C@H](C2)C(N)=O |wD:15.15,22.26,TLB:14:15:23.22.21:17.19.18,THB:24:22:17.19.18:15,(16.24,-11.07,;17.59,-10.32,;18.92,-11.1,;18.92,-9.55,;18.92,-8.01,;17.59,-7.25,;17.59,-5.72,;18.92,-4.94,;20.26,-5.71,;20.25,-7.25,;18.92,-3.41,;18.92,-1.87,;16.26,-9.55,;16.26,-8.01,;15.36,-10.05,;13.9,-9.21,;13.33,-10.79,;13.32,-13.11,;11.29,-13.06,;12.28,-12.36,;12.28,-9.68,;10.94,-9.69,;10.42,-8.75,;10.39,-10.71,;8.93,-9.14,;7.84,-8.05,;8.52,-10.63,)| | ||
| Structure | 
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