| Reaction Details |
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 | Report a problem with these data |
| Target | 7-dehydrocholesterol reductase |
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| Ligand | BDBM50407450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2266977 |
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| IC50 | 50000±n/a nM |
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| Citation |  Phull, MS; Jadav, SS; Gundla, R; Mainkar, PS A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors. Eur J Med Chem212:0 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 7-dehydrocholesterol reductase |
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| Name: | 7-dehydrocholesterol reductase |
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| Synonyms: | 7-DHC reductase | 7-dehydrocholesterol reductase | Anti-estrogen binding site (AEBS) | D7SR | DHCR7 | DHCR7_HUMAN | Putative sterol reductase SR-2 | Sterol Delta(7)-reductase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54508.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_864350 |
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| Residue: | 475 |
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| Sequence: | MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
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| BDBM50407450 |
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| n/a |
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| Name | BDBM50407450 |
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| Synonyms: | CHEMBL4544901 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H32N2O2S |
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| Mol. Mass. | 364.545 |
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| SMILES | CC1CCN(CC1)C1CCN(CC1)S(=O)(=O)c1c(C)cc(C)cc1C |
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| Structure | 
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