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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Poly [ADP-ribose] polymerase tankyrase-1 | ||
| Ligand | BDBM50407494 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2266987 | ||
| IC50 | 46±n/a nM | ||
| Citation |  Phull, MS; Jadav, SS; Gundla, R; Mainkar, PS A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors. Eur J Med Chem212:0 (2021) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Poly [ADP-ribose] polymerase tankyrase-1 | |||
| Name: | Poly [ADP-ribose] polymerase tankyrase-1 | ||
| Synonyms: | (ARTD5 or PARP5a) | PARP5A | PARPL | Poly [ADP-ribose] polymerase 5 (PARP5) | Poly [ADP-ribose] polymerase tankyrase-1 | TIN1 | TINF1 | TNKS | TNKS1 | TNKS1_HUMAN | Tankyrase 1 | Tankyrase 1/2 | Tankyrase-1 | Tankyrase-1 (TNKS-1) | Tankyrase-1 (TNKS1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 142058.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O95271 | ||
| Residue: | 1327 | ||
| Sequence: |
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| BDBM50407494 | |||
| n/a | |||
| Name | BDBM50407494 | ||
| Synonyms: | CHEMBL5276118 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H19N7O3S | ||
| Mol. Mass. | 509.539 | ||
| SMILES | Cc1ccccc1-n1c(\C=C\c2nnc(o2)-c2ccc(cc2)C#N)nnc1-c1ccc(cn1)S(C)(=O)=O |(-1.69,1.46,;-3.23,1.46,;-4.01,2.79,;-5.54,2.79,;-6.31,1.45,;-5.54,.12,;-4,.12,;-3.23,-1.21,;-1.7,-1.56,;-.61,-.47,;.88,-.87,;1.96,.22,;1.57,1.71,;2.9,2.55,;4.06,1.6,;3.49,.22,;5.55,2,;6.64,.9,;8.12,1.31,;8.52,2.79,;7.43,3.88,;5.95,3.48,;10.01,3.19,;11.49,3.59,;-1.55,-3.05,;-2.97,-3.67,;-4,-2.54,;-5.54,-2.54,;-6.31,-3.88,;-7.85,-3.88,;-8.62,-2.55,;-7.85,-1.22,;-6.31,-1.22,;-10.16,-2.55,;-10.93,-3.88,;-10.16,-1,;-11.49,-1.78,)| | ||
| Structure | 
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