| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM7266 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2267610 |
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| IC50 | 23±n/a nM |
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| Citation |  Akunuri, R; Vadakattu, M; Bujji, S; Veerareddy, V; Madhavi, YV; Nanduri, S Fused-azepinones: Emerging scaffolds of medicinal importance. Eur J Med Chem220:0 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3, beta | GSK3B_RAT | Glycogen Synthase Kinase-3, beta | Gsk3b |
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| Type: | Enzyme |
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| Mol. Mass.: | 46754.43 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | The rat GSK-3 beta cDNA was inserted into the baculovirus vector. The protein was purified from virus-infected sf9 insect cells |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDM
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST
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| BDBM7266 |
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| n/a |
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| Name | BDBM7266 |
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| Synonyms: | 14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one | 9-bromopaullone | CHEMBL296586 | Kenpaullone | NSC 664704 | Paullone Analog 5 | cid_3820 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11BrN2O |
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| Mol. Mass. | 327.175 |
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| SMILES | Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 |
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| Structure | 
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