| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 5 |
|---|
| Ligand | BDBM50411360 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2269055 |
|---|
| Kd | 25000±n/a nM |
|---|
| Citation |  Mann, MK; Zepeda-Velázquez, CA; González-Álvarez, H; Dong, A; Kiyota, T; Aman, AM; Loppnau, P; Li, Y; Wilson, B; Arrowsmith, CH; Al-Awar, R; Harding, RJ; Schapira, M Structure-Activity Relationship of USP5 Inhibitors. J Med Chem64:15017-15036 (2021) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ubiquitin carboxyl-terminal hydrolase 5 |
|---|
| Name: | Ubiquitin carboxyl-terminal hydrolase 5 |
|---|
| Synonyms: | Deubiquitinating enzyme 5 | ISOT | Isopeptidase T | UBP5_HUMAN | USP5 | Ubiquitin thioesterase 5 | Ubiquitin-specific-processing protease 5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 95751.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_974329 |
|---|
| Residue: | 858 |
|---|
| Sequence: | MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVER
HFNKTGQRVYLHLRRTRRPKEEDPATGTGDPPRKKPTRLAIGVEGGFDLSEEKFELDEDV
KIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSASRKQEVQAWDGEVRQVSKHA
FSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRET
GYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDM
NQRIGEWELIQESGVPLKPLFGPGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEK
IFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKAL
IGKGHPEFSTNRQQDAQEFFLHLINMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYT
QRVDYIMQLPVPMDAALNKEELLEYEEKKRQAEEEKMALPELVRAQVPFSSCLEAYGAPE
QVDDFWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDIS
QLRGTGLQPGEEELPDIAPPLVTPDEPKGSLGFYGNEDEDSFCSPHFSSPTSPMLDESVI
IQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLILPGSSGPGSTSAAA
DPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHIDDLDAEAAMDISEGRSA
ADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKVCAS
EKPPKDLGYIYFYQRVAS
|
|
|
|---|
| BDBM50411360 |
|---|
| n/a |
|---|
| Name | BDBM50411360 |
|---|
| Synonyms: | CHEMBL5268432 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H27N3O5S |
|---|
| Mol. Mass. | 409.5 |
|---|
| SMILES | CN1CCC2(CC1)CCN(CC2)S(=O)(=O)c1ccc(cc1)C(=O)NCC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
