| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2269421 |
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| Ki | 0.740000±n/a nM |
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| Citation |  Kashif Khan, R; Meanwell, NA; Hager, HH Pseudoprolines as stereoelectronically tunable proline isosteres. Bioorg Med Chem Lett75:0 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
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|
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| BDBM579 |
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| n/a |
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| Name | BDBM579 |
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| Synonyms: | (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[(2R)-2-[2-(isoquinolin-5-yloxy)acetamido]-3-(methylsulfanyl)propanamido]-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide | CHEMBL414640 | KNI-272 | Kynostatin 272 | iQoa-Mta-Apns-Thz-NH-tBu |
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| Type | Small organic molecule |
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| Emp. Form. | C33H41N5O6S2 |
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| Mol. Mass. | 667.839 |
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| SMILES | CSC[C@H](NC(=O)COc1cccc2cnccc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)N1CSC[C@H]1C(=O)NC(C)(C)C |r| |
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| Structure | 
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