| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Ligand | BDBM50478735 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2271375 |
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| IC50 | 600±n/a nM |
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| Citation |  Rana, P; Ghouse, SM; Akunuri, R; Madhavi, YV; Chopra, S; Nanduri, S FabI (enoyl acyl carrier protein reductase) - A potential broad spectrum therapeutic target and its inhibitors. Eur J Med Chem208:0 (2020) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Synonyms: | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase |
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| Type: | Enzyme |
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| Mol. Mass.: | 27989.00 |
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| Organism: | Staphylococcus aureus |
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| Description: | Q6GI75 |
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| Residue: | 256 |
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| Sequence: | MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK
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| BDBM50478735 |
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| n/a |
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| Name | BDBM50478735 |
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| Synonyms: | CHEBI:65655 | COMPLESTATINS A |
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| Type | Small organic molecule |
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| Emp. Form. | C61H45Cl6N7O16 |
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| Mol. Mass. | 1344.765 |
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| SMILES | [H][C@@]12NC(=O)[C@H](NC(=O)[C@@H](CC3C(=O)Nc4cc(ccc34)-c3cc1cc(Oc1ccc(C[C@H](N(C)C(=O)[C@H](NC2=O)c2cc(Cl)c(O)c(Cl)c2)C(=O)N[C@@H](C(O)=O)c2ccc(O)cc2)cc1)c3O)NC(=O)C(=O)c1cc(Cl)c(O)c(Cl)c1)c1cc(Cl)c(O)c(Cl)c1 |r| |
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| Structure | 
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