| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage metalloelastase |
|---|
| Ligand | BDBM50195899 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_452975 (CHEMBL902120) |
|---|
| Ki | 390±n/a nM |
|---|
| Citation |  Duan, JJ; Chen, L; Lu, Z; Jiang, B; Asakawa, N; Sheppeck, JE; Liu, RQ; Covington, MB; Pitts, W; Kim, SH; Decicco, CP Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). Bioorg Med Chem Lett17:266-71 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage metalloelastase |
|---|
| Name: | Macrophage metalloelastase |
|---|
| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54012.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P39900 |
|---|
| Residue: | 470 |
|---|
| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
|
|
|
|---|
| BDBM50195899 |
|---|
| n/a |
|---|
| Name | BDBM50195899 |
|---|
| Synonyms: | CHEMBL440048 | N-((5-benzyl-2,4,6-trioxo-hexahydropyrimidin-5-yl)methyl)-4-((2-methylquinolin-4-yl)methoxy)benzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H26N4O5 |
|---|
| Mol. Mass. | 522.5512 |
|---|
| SMILES | Cc1cc(COc2ccc(cc2)C(=O)NCC2(Cc3ccccc3)C(=O)NC(=O)NC2=O)c2ccccc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
