| Reaction Details |
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 | Report a problem with these data |
| Target | Stromelysin-1 |
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| Ligand | BDBM50195911 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_452972 (CHEMBL902117) |
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| Ki | >4500±n/a nM |
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| Citation |  Duan, JJ; Chen, L; Lu, Z; Jiang, B; Asakawa, N; Sheppeck, JE; Liu, RQ; Covington, MB; Pitts, W; Kim, SH; Decicco, CP Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). Bioorg Med Chem Lett17:266-71 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stromelysin-1 |
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| Name: | Stromelysin-1 |
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| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 53973.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08254 |
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| Residue: | 477 |
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| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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| BDBM50195911 |
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| n/a |
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| Name | BDBM50195911 |
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| Synonyms: | 4-((2-methylquinolin-4-yl)methoxy)-N-((2,4,6-trioxo-5-(piperidin-4-yl)-hexahydropyrimidin-5-yl)methyl)benzamide | CHEMBL240654 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29N5O5 |
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| Mol. Mass. | 515.5604 |
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| SMILES | Cc1cc(COc2ccc(cc2)C(=O)NCC2(C3CCNCC3)C(=O)NC(=O)NC2=O)c2ccccc2n1 |
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| Structure | 
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