| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Ligand | BDBM85039 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2275507 |
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| Ki | 4.0±n/a nM |
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| Citation |  Beato, A; Gori, A; Boucherle, B; Peuchmaur, M; Haudecoeur, R ?-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy. J Med Chem64:1392-1422 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Synonyms: | GABA receptor alpha-2 subunit | GABRA2 | GBRA2_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) |
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| Type: | Protein |
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| Mol. Mass.: | 51338.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47869 |
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| Residue: | 451 |
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| Sequence: | MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
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|
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| BDBM85039 |
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| n/a |
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| Name | BDBM85039 |
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| Synonyms: | CAS_121926 | NSC_121926 | ZK 93423 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N2O4 |
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| Mol. Mass. | 390.4318 |
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| SMILES | CCOC(=O)c1ncc2[nH]c3ccc(OCc4ccccc4)cc3c2c1COC |
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| Structure | 
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