Reaction Details |
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Target | Neurolysin, mitochondrial |
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Ligand | BDBM50609222 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2277154 |
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EC50 | 11700±n/a nM |
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Citation | Rahman, MS; Kumari, S; Esfahani, SH; Nozohouri, S; Jayaraman, S; Kinarivala, N; Kocot, J; Baez, A; Farris, D; Abbruscato, TJ; Karamyan, VT; Trippier, PC Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability. J Med Chem64:12705-12722 (2021) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neurolysin, mitochondrial |
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Name: | Neurolysin, mitochondrial |
Synonyms: | 3.4.24.16 | MEP | Microsomal endopeptidase | Mitochondrial oligopeptidase M | NEUL_RAT | Neurotensin endopeptidase | Nln |
Type: | PROTEIN |
Mol. Mass.: | 80252.04 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_120673 |
Residue: | 704 |
Sequence: | MITLCLSTLRGLHRAGGSRLQLTMTLGKELASPLQAMSSYTAAGRNVLRWDLSPEQIKTR
TEQLIAQTKQVYDTVGTIALKEVTYENCLQVLADIEVTYIVERTMLDFPQHVSSDREVRA
ASTEADKKLSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHL
SEHIRNEIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDEDKYK
VTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKQENTAILQQLLPLRAQVAKLLGYNTHA
DFVLELNTAKSTSRVAAFLDDLSQKLKPLGEAEREFILSLKKKECEERGFEYDGKINAWD
LHYYMTQTEELKYSVDQESLKEYFPIEVVTEGLLSIYQELLGLSFEQVPDAHVWNKSVSL
YTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMSVAALVVNFSQPV
AGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVD
SLRKLSKHYKDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNATLDAASEY
AKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFKKEGIMNPE
VGMKYRNLILKPGGSLDGMDMLQNFLQREPNQKAFLMSRGLNGS
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BDBM50609222 |
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n/a |
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Name | BDBM50609222 |
Synonyms: | CHEMBL5271948 |
Type | Small organic molecule |
Emp. Form. | C20H22N4O |
Mol. Mass. | 334.4149 |
SMILES | N[C@H](Cc1c[nH]cn1)C(=O)NCCc1ccc(cc1)-c1ccccc1 |r| |
Structure |
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