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TargetNeuropeptide Y receptor type 1
LigandBDBM50197012
Substrate/Competitorn/a
Meas. Tech.ChEMBL_453178 (CHEMBL902328)
Ki>1000±n/a nM
Citation DeCarr, LB; Buckholz, TM; Coish, PD; Fathi, Z; Fisk, SE; Mays, MR; O'Connor, SJ; Lumb, KJ Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett17:538-41 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuropeptide Y receptor type 1
Name:Neuropeptide Y receptor type 1
Synonyms:NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:Enzyme Catalytic Domain
Mol. Mass.:44399.07
Organism:Homo sapiens (Human)
Description:NPY-Y1 NPY1R HUMAN::P25929
Residue:384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50197012
n/a
NameBDBM50197012
Synonyms:CHEMBL429005
TypeSmall organic molecule
Emp. Form.C87H126N26O19
Mol. Mass.1840.0941
SMILESCC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |wU:82.86,83.89,4.4,100.104,20.28,67.71,120.124,wD:75.79,8.17,30.39,89.93,59.63,109.113,(14.12,-12.75,;14.12,-14.29,;15.46,-15.06,;12.8,-15.06,;12.8,-16.6,;11.45,-17.36,;10.12,-16.59,;10.12,-15.05,;8.79,-17.36,;8.79,-18.9,;10.12,-19.67,;11.46,-18.9,;12.79,-19.67,;12.79,-21.21,;14.1,-21.97,;11.46,-21.98,;10.12,-21.21,;7.46,-16.59,;6.13,-17.38,;6.13,-18.92,;4.8,-16.61,;4.8,-15.07,;6.13,-14.3,;7.54,-14.93,;8.57,-13.78,;7.8,-12.45,;6.29,-12.77,;3.46,-17.37,;2.13,-16.6,;2.13,-15.06,;.8,-17.37,;.8,-18.91,;2.13,-19.68,;2.13,-21.22,;3.46,-21.99,;3.47,-23.53,;2.12,-24.29,;4.78,-24.29,;-.54,-16.6,;-1.86,-17.39,;-1.86,-18.93,;-3.2,-16.62,;-4.53,-17.39,;-5.86,-16.62,;-6.04,-15.1,;-5.01,-13.96,;-5.48,-12.5,;-6.99,-12.19,;-8.01,-13.32,;-7.54,-14.77,;-8.31,-16.11,;-9.8,-16.44,;-10.27,-17.9,;-9.23,-19.04,;-7.74,-18.71,;-7.27,-17.25,;14.12,-17.37,;14.12,-18.91,;15.45,-16.59,;16.78,-17.36,;16.78,-18.9,;18.11,-19.67,;19.44,-18.9,;18.11,-21.21,;18.11,-16.59,;18.11,-15.05,;19.45,-17.36,;20.79,-16.6,;20.79,-15.06,;22.11,-14.29,;22.11,-12.75,;23.45,-15.06,;22.11,-17.37,;22.11,-18.91,;23.44,-16.59,;24.78,-17.36,;24.78,-18.9,;26.11,-19.67,;23.44,-19.67,;26.11,-16.59,;26.11,-15.05,;27.44,-17.36,;28.78,-16.59,;28.78,-15.05,;27.44,-14.28,;30.1,-14.28,;30.11,-17.36,;30.11,-18.9,;31.44,-16.59,;32.77,-17.36,;32.77,-18.9,;34.09,-19.67,;34.09,-21.21,;35.43,-21.97,;35.43,-23.51,;34.1,-24.28,;36.77,-24.28,;34.09,-16.59,;34.09,-15.05,;35.43,-17.36,;36.77,-16.59,;36.77,-15.05,;38.1,-14.28,;38.1,-12.74,;36.77,-11.97,;39.43,-11.97,;38.1,-17.36,;38.1,-18.9,;39.43,-16.59,;40.76,-17.36,;40.76,-18.9,;42.09,-19.67,;42.09,-21.21,;43.43,-21.98,;43.43,-23.52,;42.09,-24.28,;44.76,-24.28,;42.09,-16.59,;42.09,-15.05,;43.43,-17.36,;44.76,-16.59,;44.76,-15.05,;46.09,-14.28,;47.43,-15.05,;48.76,-14.28,;48.76,-12.74,;50.09,-11.97,;47.43,-11.97,;46.09,-12.74,;46.09,-17.36,;47.43,-16.59,;46.09,-18.9,)|
Structure
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