Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 1

Ligand

BDBM50197018

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_453178 (CHEMBL902328)

>1000±n/a nM

Citation

DeCarr, LB; Buckholz, TM; Coish, PD; Fathi, Z; Fisk, SE; Mays, MR; O'Connor, SJ; Lumb, KJ Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett17:538-41 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 1

Name:

Neuropeptide Y receptor type 1

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44399.07

Organism:

Homo sapiens (Human)

Description:

NPY-Y1 NPY1R HUMAN::P25929

Residue:

384

Sequence:

MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI

BDBM50197018

n/a

Name

BDBM50197018

Synonyms:

CHEMBL268200 | PYY(25-36)

Type

Small organic molecule

Emp. Form.

C72H116N26O17

Mol. Mass.

1617.8554

SMILES

CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |wU:65.66,66.69,4.4,83.84,20.28,50.51,103.104,wD:58.59,8.17,30.32,72.73,42.43,92.93,(7.74,-14.58,;7.74,-16.12,;9.08,-16.89,;6.41,-16.89,;6.41,-18.43,;5.07,-19.18,;3.73,-18.41,;3.73,-16.87,;2.41,-19.18,;2.41,-20.72,;3.73,-21.49,;5.07,-20.72,;6.41,-21.49,;6.41,-23.03,;7.72,-23.8,;5.07,-23.8,;3.73,-23.03,;1.07,-18.42,;-.25,-19.2,;-.25,-20.74,;-1.58,-18.43,;-1.58,-16.89,;-.25,-16.12,;1.15,-16.75,;2.19,-15.6,;1.42,-14.27,;-.09,-14.59,;-2.92,-19.19,;-4.26,-18.42,;-4.26,-16.88,;-5.59,-19.19,;-6.94,-18.41,;-5.59,-20.73,;-4.26,-21.5,;-4.26,-23.04,;-2.92,-23.81,;-2.91,-25.35,;-4.26,-26.11,;-1.6,-26.11,;7.74,-19.2,;7.74,-20.74,;9.07,-18.42,;10.4,-19.19,;10.4,-20.73,;11.73,-21.5,;13.05,-20.72,;11.73,-23.04,;11.73,-18.42,;11.73,-16.88,;13.06,-19.18,;14.4,-18.42,;14.4,-16.88,;15.73,-16.11,;15.73,-14.57,;17.07,-16.88,;15.73,-19.19,;15.73,-20.73,;17.06,-18.41,;18.39,-19.19,;18.39,-20.73,;19.72,-21.5,;17.06,-21.5,;19.72,-18.42,;19.72,-16.88,;21.06,-19.19,;22.39,-18.42,;22.39,-16.88,;21.06,-16.11,;23.72,-16.1,;23.72,-19.19,;23.72,-20.73,;25.05,-18.41,;26.38,-19.18,;26.38,-20.72,;27.71,-21.49,;27.71,-23.03,;29.05,-23.8,;29.05,-25.34,;27.71,-26.1,;30.38,-26.1,;27.71,-18.41,;27.71,-16.87,;29.05,-19.18,;30.39,-18.42,;30.39,-16.88,;31.71,-16.11,;31.71,-14.57,;30.38,-13.79,;33.05,-13.8,;31.71,-19.19,;31.71,-20.73,;33.04,-18.41,;34.38,-19.18,;34.38,-20.72,;35.71,-21.49,;35.71,-23.03,;37.04,-23.8,;37.04,-25.34,;35.7,-26.1,;38.38,-26.1,;35.71,-18.41,;35.71,-16.87,;37.04,-19.18,;38.38,-18.42,;38.38,-16.88,;39.71,-16.11,;41.04,-16.88,;42.38,-16.11,;42.38,-14.57,;43.71,-13.8,;41.04,-13.8,;39.71,-14.57,;39.71,-19.19,;41.04,-18.42,;39.71,-20.73,)|

Structure