Ki Summary

Reaction Details

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Target

Nuclear receptor subfamily 1 group I member 2

Ligand

BDBM50609808

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2279567

IC50

1440±n/a nM

Citation

Li, Y; Lin, W; Chai, SC; Wu, J; Annu, K; Chen, T Design and Optimization of 1 J Med Chem65:16829-16859 (2022) [PubMed]

More Info.:

Get all data from this article, Assay Method

Nuclear receptor subfamily 1 group I member 2

Name:

Nuclear receptor subfamily 1 group I member 2

Synonyms:

Type:

Nuclear receptor

Mol. Mass.:

49774.77

Organism:

Homo sapiens (Human)

Description:

O75469

Residue:

434

Sequence:

MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS

BDBM50609808

n/a

Name

BDBM50609808

Synonyms:

CHEMBL5287237

Type

Small organic molecule

Emp. Form.

C26H34N4O4

Mol. Mass.

466.5726

SMILES

CCCCOc1ccc(cc1NC(=O)c1nnn(c1C)-c1c(OC)cccc1OC)C(C)(C)C |(-1.78,-5.91,;-1.01,-4.57,;.53,-4.57,;1.3,-3.24,;2.84,-3.24,;3.61,-1.9,;5.15,-1.9,;5.91,-.57,;5.14,.77,;3.6,.77,;2.83,-.57,;1.29,-.57,;.52,.77,;1.29,2.1,;-1.02,.77,;-1.79,-.56,;-3.29,-.24,;-3.45,1.29,;-2.05,1.91,;-1.65,3.4,;-4.79,2.06,;-6.11,1.29,;-6.11,-.25,;-4.78,-1.02,;-7.45,2.05,;-7.45,3.6,;-6.12,4.36,;-4.79,3.6,;-3.45,4.37,;-3.45,5.91,;5.91,2.1,;5.14,3.43,;7.45,2.1,;6.68,3.43,)|

Structure