| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM50197491 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_432257 (CHEMBL914035) |
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| IC50 | 17±n/a nM |
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| Citation |  Pham-Huu, DP; Deschamps, JR; Liu, S; Madras, BK; Meltzer, PC Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem15:1067-82 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | SC6A4_MACMU | SLC6A4 | Serotonin transporter |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70256.94 |
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| Organism: | Macaca mulatta |
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| Description: | ChEMBL_432257 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKQLSACKDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPAATTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSFVCIPTYIAYRLIST
PGTFKERIIKSITPETPTEIPCGDVRLNAV
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| BDBM50197491 |
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| n/a |
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| Name | BDBM50197491 |
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| Synonyms: | 2-beta-carbomethoxy-3-beta-(4-chloro-3-fluorophenyl)-8-thiabicyclo[3.2.1]octane | CHEMBL227720 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16ClFO2S |
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| Mol. Mass. | 314.803 |
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| SMILES | COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)c(F)c1)S2 |TLB:11:10:19:6.7,THB:2:4:19:6.7| |
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| Structure | 
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