| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50197461 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_432256 (CHEMBL914034) |
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| IC50 | 1000±n/a nM |
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| Citation |  Pham-Huu, DP; Deschamps, JR; Liu, S; Madras, BK; Meltzer, PC Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem15:1067-82 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DAT1 | Dopamine transporter | SC6A3_MACFA | SLC6A3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68455.12 |
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| Organism: | Macaca fascicularis |
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| Description: | ChEMBL_61362 |
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| Residue: | 620 |
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| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAMGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHSGDSGGNGPGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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| BDBM50197461 |
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| n/a |
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| Name | BDBM50197461 |
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| Synonyms: | 2-beta-carbomethoxy-3-alpha-phenyl-8-oxo-8-thiabicyclo[3.2.1]octane | CHEMBL227878 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18O3S |
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| Mol. Mass. | 278.367 |
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| SMILES | COC(=O)[C@@H]1C2CCC(C[C@H]1c1ccccc1)S2=O |TLB:11:10:17:6.7,THB:2:4:17:6.7| |
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| Structure | 
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