| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-2 |
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| Ligand | BDBM50199445 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_413225 (CHEMBL910646) |
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| IC50 | 51000±n/a nM |
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| Citation |  Tervo, AJ; Suuronen, T; Kyrylenko, S; Kuusisto, E; Kiviranta, PH; Salminen, A; Leppänen, J; Poso, A Discovering inhibitors of human sirtuin type 2: novel structural scaffolds. J Med Chem49:7239-41 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-2 |
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| Name: | NAD-dependent protein deacetylase sirtuin-2 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 43172.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 389 |
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| Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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| BDBM50199445 |
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| n/a |
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| Name | BDBM50199445 |
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| Synonyms: | (E)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-(3-(4-(4-fluorobenzyloxy)phenyl)acrylamido)piperidine-4-carboxamide | 4-(3-(4-(4-fluorobenzyloxy)phenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide | CHEMBL215918 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H32F2N4O3 |
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| Mol. Mass. | 558.6183 |
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| SMILES | Fc1ccc(COc2ccc(\C=C\C(=O)NC3(CCNCC3)C(=O)NCCc3c[nH]c4ccc(F)cc34)cc2)cc1 |
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| Structure | 
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