| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptide Y receptor type 1 |
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| Ligand | BDBM50199585 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453427 (CHEMBL885426) |
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| IC50 | 51±n/a nM |
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| Citation |  Leslie, CP; Di Fabio, R; Bonetti, F; Borriello, M; Braggio, S; Dal Forno, G; Donati, D; Falchi, A; Ghirlanda, D; Giovannini, R; Pavone, F; Pecunioso, A; Pentassuglia, G; Pizzi, DA; Rumboldt, G; Stasi, L Novel carbazole derivatives as NPY Y1 antagonists. Bioorg Med Chem Lett17:1043-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptide Y receptor type 1 |
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| Name: | Neuropeptide Y receptor type 1 |
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| Synonyms: | NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44399.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | NPY-Y1 NPY1R HUMAN::P25929 |
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| Residue: | 384 |
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| Sequence: | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI
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| BDBM50199585 |
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| n/a |
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| Name | BDBM50199585 |
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| Synonyms: | (1-(4-chlorophenoxy)-9-(((3R,4S)-3-fluoropiperidin-4-yl)methyl)-9H-carbazol-3-yl)(4-methylpiperazin-1-yl)methanone | CHEMBL240404 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32ClFN4O2 |
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| Mol. Mass. | 535.052 |
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| SMILES | CN1CCN(CC1)C(=O)c1cc(Oc2ccc(Cl)cc2)c2n(C[C@@H]3CCNC[C@@H]3F)c3ccccc3c2c1 |
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| Structure | 
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